Since nursing deals a lot with interaction to patients and your co-workers if you are a shy person then meeting new people constantly may also be a drawback. If you take a long time to build a good working interaction with your co-workers becoming a traveling nurse may be a drawback.
As a traveling nurse you need to be able to adjust to out of the ordinary situations and the unexpected. If you like and are more comfortable in surroundings that you know and are familiar with then a career as a traveling nurse may not be the wise choice for you as you are constantly changing your surroundings. When you travel things can go wrong, no mater how much you have planned no matter how much detail you have put into your plans the unexpected will happen. If you are uncomfortable dealing with problems that can arise during travels then you may want to look into a more contemporary nursing job. If you love the security of home life a traveling nurse moves around a lot and their home is in various parts of the country while they are employed by different assignments.
If you are the type of person who likes to be close to their family and can not deal with being away from their family for long periods of times then you need to be aware that a traveling nurse can be gone for roughly 6 week periods of time to much longer. A typical assignment lasts from 6 weeks on up to 52 weeks. The one plus to this is that you can choose your assignments and choose the places you are willing to relocate so if you wish to only go a matter of a few hours away or 2 days away the choice is yours to accept an assignment or not.